Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome which crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention and with the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In this 1997 volume, the editors bring together a distinguished team of contributors to describe the aetiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of authors' expertise, this comprehensive volume should prove invaluable to internists, gastroenterologists, surgeons, and intensive care providers.
- Was the first volume dedicated exclusively to acute liver failure
- Contributors represent premier liver centres in North America, Europe and the UK
- Comprehensive guide to acute liver failure diagnosis, treatment and transplantation issues
- Covers developments in liver support devices, and future treatments such as hepatocyte transplantation
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Reviews & endorsements
Review of the hardback: '… an excellent update of the current concepts of a complex syndrome … It is the first textbook solely devoted to this important topic. The book is written by several prominent clinicians and researchers who have given thoughtful and excellent overviews of different aspects of acute liver failure … The book has many strengths. It is current, comprehensive, well written, and well organised, all of which make it very easy to read. Most of all, this ambitious endeavour serves all the audiences that it targets.' The Lancet
Review of the hardback: 'This book is a landmark in the field and worthy of monograph status.' Doody's Health Sciences Book Review Journal
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Product details
- Date Published: June 2011
- format: Paperback
- isbn: 9780521188944
- length: 336 pages
- dimensions: 254 x 178 x 17 mm
- weight: 0.58kg
- availability: Available
Table of Contents
Part I. Clinical Syndrome and Etiology:
1. Classification and clinical syndromes of Acute Liver Failure
2. Viral hepatitis and Acute Liver Failure
3. Drug hepatoxicity and Acute Liver Failure
4. Acetaminophen-related Acute Liver Failure
5. Unusual causes of Acute Liver Failure
6. Pediatric aspects of Acute Liver Failure
Part II. Mechanisms of Disease and Multisystem Involvement:
7. The role of cytokines and immune mechanisms in Acute Liver Failure
8. The pathology of Acute Liver Failure
9. Hepatic replication and liver regeneration
Part III. Intensive Care Management
10. Medical management of Acute Liver Failure
11. Circulatory derangements: monitoring and management of heart, kidney and brain
12. Brain edema and intracranial hypertension in Acute Liver Failure
13. Management of infection in Acute Liver Failure
Part IV. Transplantation:
14. Prognosis and consideration of transplantation
15. Liver transplantation in patients with Acute Liver Failure: the European experience
16. Liver transplantation in patients with Acute Liver Failure: the American experience
17. Auxiliary liver transplantation
Part V. Artificial and Bioartifical Liver Devices:
18. Extracorporeal liver support: historical background and critical analysis
19. Hepatocyte culture and bioreactor design for liver support systems
20. Clinical experience with an extracorporeal liver assist device (ELAD)
Part VI. Other Approaches:
21. Treatment of Acute Liver Failure by high volume plasmapheresis
22. Dialysis/adsorption techniques for Acute Liver Failure
23. Hepatocyte transplantation in liver failure and inherited metabolic disorders.

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Editors
William M. Lee, University of Texas Southwestern Medical Center, Dallas
Roger Williams, University College London
Foreword
Jean-Pierre Benhamou
Jacques Bernuau