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Look Inside The Biology of Oligodendrocytes

The Biology of Oligodendrocytes

£116.00

Editors:
Patricia Armati, University of Sydney
Emily Mathey, University of Sydney

Emily Mathey, Ariel Arthur, Patricia Armati, Rudolf Martini, Janos Groh, Udo Bartsch, Robert H. Miller, Grahame Kidd, Bruce D. Trapp, Joseph A. Nielsen, Pierre Lau, Lynn D. Hudson, David Kremer, Orhan Aktas, Hans-Peter Hartung, Patrick Küry, Neil Scolding, Jurate Lasiene, Philip J. Horner, Tanja Kuhlmann, Wolfgang Brück, Tara M. Desilva, Paul A. Rosenberg

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Date Published: October 2010
availability: Available
format: Hardback
isbn: 9780521899659

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Description

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About the Authors

Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
- The first book dedicated to the oligodendrocytes, key cells in the mammalian central nervous system
- A one-stop resource for current research on these cells, covering all important aspects of their biology
- Chapters exploring multiple sclerosis give the reader an important insight into the role of oligodendrocytes in neural disease
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Product details
- Date Published: October 2010
- format: Hardback
- isbn: 9780521899659
- length: 304 pages
- dimensions: 235 x 155 x 20 mm
- weight: 0.62kg
- contains: 25 b/w illus. 10 colour illus.
- availability: Available
Table of Contents
List of contributors
Preface
1. CNS oligarchs. The rise of the oligodendrocyte in a neuron-centric culture Emily Mathey, Ariel Arthur and Patricia Armati
2. Comparative biology of Schwann cells and oligodendrocytes Rudolf Martini, Janos Groh and Udo Bartsch
3. Control of oligodendrocyte development and myelination in the vertebrate CNS Robert H. Miller
4. Molecular organization of the oligodendrocyte and myelin Grahame Kidd and Bruce D. Trapp
5. The genetics of oligodendrocytes Joseph A. Nielsen, Pierre Lau and Lynn D. Hudson
6. Immunobiology of the oligodendrocyte David Kremer, Orhan Aktas, Hans-Peter Hartung and Patrick Küry
7. Oligodendrocytes and disease: repair, remyelination and stem cells Neil Scolding
8. Glial progenitor cells and the dynamics of the oligodendrocyte and its myelin in the aged and injured CNS Jurate Lasiene and Philip J. Horner
9. Oligodendroglial pathology in MS Tanja Kuhlmann and Wolfgang Brück
10. Glutamate receptors, transporters, and periventricular leukomalacia Tara M. Desilva and Paul A. Rosenberg
References
Index.
Look Inside
Editors
Patricia Armati, University of Sydney
Patricia Armati is Associate Professor of Neuroscience and co-director of the Nerve Research Foundation, Brain and Mind Research Institute at the University of Sydney, Australia. She has a long standing interest in the cells of the nervous system and the relationship to disease and is editor of The Biology of Schwann Cells (Cambridge University Press, 2007).
Emily Mathey, University of Sydney
Emily Mathey is a postdoctoral scientist at the Brain and Mind Research Institute at the University of Sydney. She has a keen interest in both immunology and neurobiology with particular emphasis on pathogenic antibody responses in demyelinating disease of the peripheral and central nervous systems.
Contributors
Emily Mathey, Ariel Arthur, Patricia Armati, Rudolf Martini, Janos Groh, Udo Bartsch, Robert H. Miller, Grahame Kidd, Bruce D. Trapp, Joseph A. Nielsen, Pierre Lau, Lynn D. Hudson, David Kremer, Orhan Aktas, Hans-Peter Hartung, Patrick Küry, Neil Scolding, Jurate Lasiene, Philip J. Horner, Tanja Kuhlmann, Wolfgang Brück, Tara M. Desilva, Paul A. Rosenberg