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Singularities

Singularities
Landmarks on the Pathways of Life

  • Date Published: October 2005
  • availability: Available
  • format: Hardback
  • isbn: 9780521841955

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About the Authors
  • Erwin Schrödinger's What is Life? published 60 years ago, influenced much of the development of molecular biology. In this new book Christian De Duve, Nobel Laureate and pioneer of modern cell biology, presents a contemporary response to this classic, providing a sophisticated consideration of the key steps or bottlenecks that constrain the origins and evolution of life. De Duve surveys the entire history of life, including insights into the conditions that may have led to its emergence. He uses as landmarks the many remarkable singularities along the way, such as the single ancestry of all living beings, the universal genetic code, and the monophyletic origin of eukaryotes. The book offers a brief guided tour of biochemistry and phylogeny, from the basic molecular building blocks to the origin of humans. Each successive singularity is introduced in a sequence paralleling the hypothetical development of features and conditions on the primitive earth, explaining how and why each transition to greater complexity occurred.

    • Author won the Nobel Prize in physiology or medicine, and is one of the pioneers of cell biology
    • The book lays out, for a scientifically sophisticated readership, a vision and perspective on the successive constraining events that have determined the course of life's evolution on earth, as well as de Duve's views on how life may have originated
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    Reviews & endorsements

    "This book is unquestionably for serious students of biology, biochemistry, and evolution, but anyone willing to work through the details will find a logical tour de force and a powerful illustration of the beauty of evolution."
    Choice

    "This volume is well written and readable, and I enjoyed de Duve's unique perspective on this difficult topic, which is invariably multidisciplinary...Singularities is an excellent book, and recommended reading for anyone interested in the fundamental questions of life and its origins."
    The Quarterly Review of Biology, S.Blair Hedges, Pennsylvania State University

    "... lucid and superbly organized..."
    BioScience

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    Product details

    • Date Published: October 2005
    • format: Hardback
    • isbn: 9780521841955
    • length: 274 pages
    • dimensions: 237 x 158 x 20 mm
    • weight: 0.576kg
    • contains: 15 b/w illus.
    • availability: Available
  • Table of Contents

    1. Building blocks
    2. Homochirality
    3. Protometabolism
    4. ATP
    5. Electrons and protons
    6. Thioesters
    7. RNA
    8. Proteins
    9. DNA
    10. Membranes
    11. Protonmotive force
    12. Protometabolism revisited
    13. The LUCA
    14. The first fork
    15. Eukaryotes
    16. Oxygen
    17. Endosymbionts
    18. Multicellular organisms
    19. Homo
    20. Evolution revisited.

  • Author

    Christian de Duve, Rockefeller University, New York

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