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Bacterial-Epithelial Cell Cross-Talk
Molecular Mechanisms in Pathogenesis

Part of Advances in Molecular and Cellular Microbiology

Editor: Beth A. McCormick, Harvard University, Massachusetts

W. Vallen Graham, Jerrold R. Turner, Anthony Maurelli, Helen J. Betts, Christopher M. Bailey, Mark J. Pallen, Ian Henderson, Matam Vijay-Kumar, Andrew Gewirtz, Glenn Young, Christof Hauck, Joseph Barbieri, Brit Winnen, Wolf-Detrich Hardt, Bobby Cherayil, Beth A. McCormick, Randall J. Mrsny, Marisa I. Gómez, Alice Prince, D. Scott Merrell, Samuel Tesfay, Donnie Edward Shifflett, Gail Hecht, Luce Landraud, René Clément, Patrice Boquet

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Date Published: September 2006
availability: Available
format: Hardback
isbn: 9780521852449

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About the Authors

An emerging theme in molecular and cellular microbiology has been the ability of many pathogens to usurp the host cell and eventually colonize the host. This interaction between bacteria and host is not unidirectional - both pathogens and host cells engage in a signalling cross-talk. Research focused on this cross-talk and discussed in this volume, reveals not only novel aspects of bacterial pathogenesis, but also key information about epithelial biology with broader implications in the prevention and treatment of infectious diseases. Written by leading researchers in this field, this book provides a valuable overview of the host-bacterial interactions that occur at mucosal surfaces including the gastrointestinal, respiratory, and urogenital tracts. It will therefore be a valuable resource for graduate students and researchers working on these systems or in the fields of molecular and cellular microbiology or infectious disease medicine.
- The most up-to-date overview available of this key topic in molecular microbiology
- Written with a cross-disciplinary audience in mind and includes an introduction to the processes involved in bacterial pathogenicity - how bacteria enter our bodies and cause infection
- Includes contributions from both clinical and scientific researchers to give the complete picture
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Product details
- Date Published: September 2006
- format: Hardback
- isbn: 9780521852449
- length: 452 pages
- dimensions: 236 x 160 x 27 mm
- weight: 0.854kg
- contains: 34 b/w illus. 4 colour illus. 15 tables
- availability: Available
Table of Contents
Part I. Introduction to the Host and Bacterial Pathogens:
1. Overview of the epithelial cell W. Vallen Graham and Jerrold R. Turner
2. Evolution of bacterial pathogens Anthony Maurelli
Part II. Bacterial Cell Biology and Pathogenesis:
3. Bacterial secretion systems Helen J. Betts, Christopher M. Bailey, Mark J. Pallen and Ian Henderson
4. Pathogen-associated molecular patterns and host detection Matam Vijay-Kumar and Andrew Gewirtz
5. Flagella regulation and its secretion system Glenn Young
6. The role of bacterial adhesion in bacterial pathogenesis Christof Hauck
7. The role of bacterial toxins in bacterial pathogenesis Joseph Barbieri
Part III. Host Cell Signaling by Bacteria:
8. Host-mediated invasion Brit Winnen and Wolf-Detrich Hardt
9. NF- kB dependent pathways Bobby Cherayil
10. NF- kB independent pathways Beth A. McCormick and Randall J. Mrsny
Part IV. Exploitation of Host Niches by Pathogenic Bacteria: Mechanisms and Consequences:
11. Lung infections Marisa I. Gómez and Alice Prince
12. Interactions of Helicobacter pylori with the gastric mucosa D. Scott Merrell
13. Interactions of enteric bacteria with the intestinal mucosa Samuel Tesfay, Donnie Edward Shifflett and Gail Hecht
14. Uropathogenic bacteria Luce Landraud, René Clément and Patrice Boquet.
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Editor
Beth A. McCormick, Harvard University, Massachusetts
Beth A. McCormick is an Associate Professor of Pediatrics and Microbiology at Harvard Medical School and the Department of Pediatric Gastroenterology and Nutrition at Massachusetts General Hospital.
Contributors
W. Vallen Graham, Jerrold R. Turner, Anthony Maurelli, Helen J. Betts, Christopher M. Bailey, Mark J. Pallen, Ian Henderson, Matam Vijay-Kumar, Andrew Gewirtz, Glenn Young, Christof Hauck, Joseph Barbieri, Brit Winnen, Wolf-Detrich Hardt, Bobby Cherayil, Beth A. McCormick, Randall J. Mrsny, Marisa I. Gómez, Alice Prince, D. Scott Merrell, Samuel Tesfay, Donnie Edward Shifflett, Gail Hecht, Luce Landraud, René Clément, Patrice Boquet