Genetic Variation and Human Disease
Principles and Evolutionary Approaches
$54.99 (P)
Part of Cambridge Studies in Biological and Evolutionary Anthropology
- Author: Kenneth M. Weiss, Pennsylvania State University
- Date Published: January 1995
- availability: Available
- format: Paperback
- isbn: 9780521336604
$
54.99
(P)
Paperback
Looking for an examination copy?
If you are interested in the title for your course we can consider offering an examination copy. To register your interest please contact [email protected] providing details of the course you are teaching.
-
Modern laboratory and computing advances have made it possible to identify which genes are responsible for a disease (or other biological traits) and to identify those genes. This book presents a survey of the methods that are being used to generate these successes, especially to study disease in families. The methods of epidemiology and genetics are surveyed, and related to molecular genetic data, with examples from both pediatric and chronic disease. The pattern of variation that has been found is best understood from the evolutionary perspective. Because these methods and ideas apply to any biological trait, not just to disease, this is a general book about the genetic control of biological traits.
Read more- Topical subject (human genome project is very high profile)
- Good reviews for hardback edition
- No other up-to-date book covers this range of topics
Reviews & endorsements
"...a most useful reference for those who wish to familiarize themselves with the area in general and to gain some comprehension of its methodologies." Roger W. Melvold, Doody's Health Science Book Review Journal
See more reviews"...provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred....will appeal to a wide range of biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists." Human Genome Abstracts
"...provides a comprehensive yet readable account of concepts and methods new to genetic epidemiology and molecular biology, which allows examination of the genetic basis of biological traits." N. Krusko, Choice
"...well-documented, clearly written, scholarly text...will certainly be valuable to students of genetics, epidemiology, molecular biology and biological anthropology, and to all who are interested in solving the molecular etiology of disease phenotypes and in studying the human gene pool and its behavior throughout evolution." Trends in Genetics
"...the value of the book lies in the mixing of quantitative methods of empirical findings of modern biology." Jonathan Flint, Times Higher Education Supplement
"This is a very fine and rewarding work. We find here no less than an explanation of the current status of, and a means for understanding, the rising flood of information on human genetic variability." William Klitz, Quarterly Review of Biology
Customer reviews
Not yet reviewed
Be the first to review
Review was not posted due to profanity
×Product details
- Date Published: January 1995
- format: Paperback
- isbn: 9780521336604
- length: 380 pages
- dimensions: 229 x 152 x 21 mm
- weight: 0.56kg
- contains: 71 b/w illus. 42 tables
- availability: Available
Table of Contents
Preface
Part I. Genes and Their Expression:
1. What is a gene?
2. The logic of the genome
3. Concepts of frequency and association in populations
4. Genes and phenotypes in populations
Part II. Introduction to Genetic Epidemiology: Inference from Observational Data:
5. Segregation analysis: discrete traits in families
6. Segregation analysis: quantitative traits in families
7. Linkage analysis: finding and mapping genes for qualitative traits
8. Linkage analysis: finding and mapping genes for quantitative traits
Part III. Evolution: The Time Dimension in Populations:
9. Genes over time and space
10. Reconstructing history: the footprints of evolution
11. Evolution generates heterogeneity
Part IV. Modification of the Inherited Genotype: The Time Dimension in Individuals:
12. Phenotype amplification by the environment
13. Infectious disease: the response to biological challenge
14. Variation within the inherited genotype
15. Cancer and ageing: a microcosm of evolution during life
Afterwords: towards a unified general model
Conclusion
Notes
References
Index.
Sorry, this resource is locked
Please register or sign in to request access. If you are having problems accessing these resources please email [email protected]
Register Sign in» Proceed
You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner www.ebooks.com. Please see the permission section of the www.ebooks.com catalogue page for details of the print & copy limits on our eBooks.
Continue ×Are you sure you want to delete your account?
This cannot be undone.
Thank you for your feedback which will help us improve our service.
If you requested a response, we will make sure to get back to you shortly.
×