Mechanisms in Blood Coagulation, Fibrinolysis and the Complement System
$69.99 (C)
- Author: Torben Halkier, Aarhus Universitet, Denmark
- Translator: Paul Woolley
- Date Published: August 2008
- availability: Available
- format: Paperback
- isbn: 9780521071833
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Blood coagulation and fibrinolysis has been traditionally classed as a part of hematology and the complement system as a part of immunology. An analysis of these two systems at a molecular level, however, has revealed some intriguing evolutionary relationships among some of the macromolecules involved. Evidently, there are similarities in the cascade of reactions that characterize the processes. It is therefore highly suitable that these topics are presented together in one volume. This book presents a thorough explanation and analysis of our current understanding of the proteins and enzymes involved in each of the three processes, and includes a section devoted to special topics of relevance, such as the kinin system, glycosylation, signal peptides, and the serpin family.
Read more- Brings together the fields of haematology and immunology for a study of the proteins involved in blood coagulation, fibrinolysis and the complement system
Reviews & endorsements
"...an excellent survey of a very complex subject." General Pharmacology
See more reviews"...recommended for researchers and graduate or advanced undergraduate students in molecular biology and biochemistry...." Robert W. Colman, American Journal of Physiology
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×Product details
- Date Published: August 2008
- format: Paperback
- isbn: 9780521071833
- length: 484 pages
- dimensions: 234 x 156 x 24 mm
- weight: 0.69kg
- contains: 223 b/w illus. 13 tables
- availability: Available
Table of Contents
Foreword
Introduction
Part I. Blood Coagulation:
1. The coagulation process: an introduction
2. Contact activation
3. Activation of factor IX
4. Activation of factor X in the intrinsic pathway
5. Activation of prothrombin
6. Activations in the extrinsic pathway
7. Formation and stabilisation of fibrin
8. Regulation of blood coagulation
Part II. Fibrinolysis:
9. Complements of the fibrinolytic system
10. Mechanisms of fibrinolysis
Part III. The Complement System:
11. Overview of the complement system
12. Classical activation of the complement system
13. Alternative activation of the complement system
14. The lytic complex (MAC)
15. Regulation processes in the complement system
16. Anaphylatoxin inactivator
17. Complement reactors
Part IV. Special Topics:
18. The kinin system
19. Glycosylation
20. Signal peptides
21. Modification of amino-acid residues
22. Coagulation-active surfaces in vivo
23. The binding of proteins to coagulation-active surfaces
24. Haemostasis
25. Integrins
26. Serpins
27. Some evolutionary considerations
Appendix
References
Index.
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